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We tested adjuvant chemotherapy combining dibromodulcitol(DBD)and bischloroethylnitrosourea(BCNU)given postoperatively to adults with newly diagnosed supratentorial malignant gliomas.Methods:We enrolled 269 patients,255 of whom were eligible.After surgery,we treated all patients with radiation therapy,using a median dose of 60 Gy given in 30 fractions. After randomization,patient in the chemotherapy group also received(1)six weekly courses,administered during irradiation,of DBD 700 mg/m2 and(2)one to nine(median four)courses administered during first year following radiation therapy,of DBD 1,000 mg/m2 on day 1 and BCNU 150 mg/m2 on day 2, with the course being repeated every 6 weeks.Results:Patients treated with radiation therapy along with DBD plus BCNU(group 2)had significantly longer survival time(p=0.044)and time to progression(p=0.003)than did those treated with radiation therapy alone(group 1).The median survival time was 13.0 months for group 2 and 10.4 months for group 1;the median time to progression was 8.1 months for group 2 and 6.7 months for group 1. The percentage of patients alive at 18 and 24 months was 34%and 21%in group 2 compared with 21%and 12%in group 1.Conclusion:DBD plus BCNU is an effective adjuvant therapy for malignant glioma. |
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chemotherapy,CNS treatment and complications with
glioblastoma multiforme(astrocytoma Gr.III)
neoplasm,primary intracerebral
neoplasm,primary of CNS
neoplasm,primary of CNS-treatment of
treatment of neurologic disorder
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